SLK antibody (pTyr530) (Biotin)

Catalog No. ABIN2179280

Product Details anti-SLK Antibody (Biotin)

Target: SLK (STE20-Like Kinase (SLK))

Binding Specificity: pTyr530

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLK antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human FYN around the phosphorylation site of Tyr530

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SLK

Target: SLK (STE20-Like Kinase (SLK))

Alternative Name: SLK (SLK Products)

Synonyms: BcDNA:LD05623 antibody, CG40293 antibody, Dmel\\CG40293 antibody, LD05623 antibody, LOSK antibody, STK2 antibody, bA16H23.1 antibody, se20-9 antibody, 9A2 antibody, AV021402 antibody, AW411554 antibody, Etk4 antibody, SMAK antibody, Stk2 antibody, mKIAA0204 antibody, mSLK antibody, STE20 like kinase antibody, Ste20-like kinase antibody, STE20-like kinase antibody, SLK antibody, Stlk antibody, Slk antibody

Background:

Synonyms: Fyn phospho Y530, p-Fyn phospho Y530, C syn protooncogene, FYN oncogene related to SRC FGR YES_ MGC45350_ OKT3 induced calcium influx regulator_ P59 FYN, Protein tyrosine kinase fyn, Proto oncogene tyrosine protein kinase fyn, Protooncogene Syn, SLK, Src like kinase, Src yes related novel gene, Src/yes related novel gene, SYN, FYN, Tyrosine kinase p59fyn T, Tyrosine kinase p59fynT.

Background: Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59 kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn is very strongly similar to mouse Fyn, v-yes and c-src. Fyn is expressed predominately in tissues of neuronal and hematopoietic origin. Neuronal Fyn and hematopoietic Fyn differ at the junction of the SH2 and kinase domains due to tissue specific alternative splicing. Fyn has been shown to be involved in B cell and T cell activation as well as keratinocyte differentiation. In T cells, Fyn associates with the T-cell antigen receptor and Thy1. The unique N terminal domain of Fyn interacts with the CD3 and eta chains of the TcR. Fyn can bind to other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of Fyn activity. Fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation.

Gene ID: 2534