MPL antibody (AA 401-500) (AbBy Fluor® 488)

Catalog No. ABIN2177733

Product Details anti-MPL Antibody (AbBy Fluor® 488)

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Binding Specificity: AA 401-500

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPL antibody is conjugated to AbBy Fluor® 488

Application: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MPL

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-MPL antibody (AbBy Fluor® 488) (ABIN2177733)

Maekawa, Osawa, Izumi, Nagao, Takano, Okada, Tachi, Teramoto, Kawamura, Horiuchi, Saga, Kato, Yamamura, Watanabe, Kobayashi, Kobayashi, Sato, Hashimoto, Suzu, Kimura: "Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis." in: Leukemia, (2017) (PubMed).

Target Details for MPL

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Alternative Name: MPL (MPL Products)

Synonyms: C-MPL antibody, CD110 antibody, MPLV antibody, THCYT2 antibody, TPOR antibody, TPO-R antibody, c-mpl antibody, c-mpl-I antibody, c-mpl-II antibody, hlb219 antibody, MPL antibody, mpll antibody, tpor antibody, tpor.b antibody, MPL proto-oncogene, thrombopoietin receptor antibody, myeloproliferative leukemia virus oncogene antibody, MPL antibody, Mpl antibody, mpl antibody

Background:

Synonyms: MPLV, TPOR, C-MPL, CD110, THCYT2, Thrombopoietin receptor, TPO-R, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, MPL

Background: Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

Gene ID: 4352

UniProt: P40238

Pathways: JAK-STAT Signaling