FAM48A/P38IP antibody (AA 21-120) (Biotin)

Catalog No. ABIN2174051

Product Details anti-FAM48A/P38IP Antibody (Biotin)

Target: FAM48A/P38IP (SUPT20H) (Suppressor of Ty 20 Homolog (SUPT20H))

Binding Specificity: AA 21-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM48A/P38IP antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAM48A

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for FAM48A/P38IP

Target: FAM48A/P38IP (SUPT20H) (Suppressor of Ty 20 Homolog (SUPT20H))

Alternative Name: FAM48A (SUPT20H Products)

Synonyms: SUPT20H antibody, AA667204 antibody, AI450544 antibody, D3Ertd300e antibody, Fam48a antibody, Supt20h antibody, p38IP antibody, RGD1307812 antibody, C13 antibody, C13orf19 antibody, FAM48A antibody, P38IP antibody, SPT20 antibody, bA421P11.4 antibody, SPT20 homolog, SAGA complex component antibody, suppressor of Ty 20 antibody, SUPT20H antibody, Supt20 antibody, Supt20h antibody

Background:

Synonyms: FAM48A is a 779 amino acid protein that interacts with p38 MAP kinase. Specifically, FAM48A and p38 are required for downregulation of E-cadherin during gastrulation. In adult tissues, FAM48A is highly expressed in testis and moderately expressed in brain and pituitary gland. It is also expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression of FAM48A has been shown to be downregulated in malignant prostate tissues. The gene encoding FAM48A maps to human chromosome 13, which houses over 400 genes and comprises approximately 4 % of the human genome. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene.

Background: FAM48A is a 779 amino acid protein that interacts with p38 MAP kinase. Specifically, FAM48A and p38 are required for downregulation of E-cadherin during gastrulation. In adult tissues, FAM48A is highly expressed in testis and moderately expressed in brain and pituitary gland. It is also expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression of FAM48A has been shown to be downregulated in malignant prostate tissues. The gene encoding FAM48A maps to human chromosome 13, which houses over 400 genes and comprises approximately 4 % of the human genome. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene.