CSRP2 antibody (AA 101-200)

Catalog No. ABIN2173630

Product Details anti-CSRP2 Antibody

Target: CSRP2 (Cysteine and Glycine-Rich Protein 2 (CSRP2))

Binding Specificity: AA 101-200

Reactivity: Mouse, Rat, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSRP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Chicken, Mouse, Rat

Predicted Reactivity: Human,Dog,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DNM1L

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CSRP2 antibody (ABIN2173630)

Hui, Lu, Han, Zhou, Liu, Li, Jin: "Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats." in: Acta histochemica, Vol. 119, Issue 4, pp. 392-399, (2017) (PubMed).

Ku, Ji, Zhang, Li, Sang: "PM2.5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain." in: Chemosphere, Vol. 163, pp. 27-34, (2016) (PubMed).

Chen, Xie, Huang, Gong, Zhu, Chen, Huang, Huang: "Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells." in: Free radical biology & medicine, Vol. 102, pp. 77-86, (2016) (PubMed).

Target Details for CSRP2

Target: CSRP2 (Cysteine and Glycine-Rich Protein 2 (CSRP2))

Alternative Name: DLP1 (CSRP2 Products)

Synonyms: CRP2 antibody, LMO5 antibody, SmLIM antibody, crp2 antibody, lmo5 antibody, csrp1 antibody, smlim antibody, AW551867 antibody, Crp2 antibody, SmLim antibody, zgc:77740 antibody, BETA-CRP antibody, csrp2 antibody, MGC81964 antibody, CSRP2 antibody, cysteine and glycine rich protein 2 antibody, cysteine and glycine-rich protein 2 antibody, cysteine and glycine rich protein 2 L homeolog antibody, cysteine and glycine rich protein 2 S homeolog antibody, CSRP2 antibody, csrp2 antibody, Csrp2 antibody, csrp2.L antibody, csrp2.S antibody

Background:

Synonyms: Dynamin-1-like protein, Dnm1p/Vps1p-like protein, DVLP, Dynamin family member proline-rich carboxyl-terminal domain less, Dymple, Dynamin-like protein, Dynamin-like protein 4, Dynamin-like protein IV, HdynIV, Dynamin-related protein 1, DNM1L, DLP1, DRP1

Background: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Gene ID: 10059

UniProt: O00429