CTNNA3 antibody (AA 131-230) (Biotin)

Catalog No. ABIN2173435

Product Details anti-CTNNA3 Antibody (Biotin)

Target: CTNNA3 (Catenin (Cadherin-Associated Protein), alpha 3 (CTNNA3))

Binding Specificity: AA 131-230

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTNNA3 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTNNA3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CTNNA3

Target: CTNNA3 (Catenin (Cadherin-Associated Protein), alpha 3 (CTNNA3))

Alternative Name: CTNNA3 (CTNNA3 Products)

Synonyms: 4930429L08Rik antibody, 4933408A16 antibody, Catna3 antibody, Vr22 antibody, RGD1559455 antibody, RGD1562230 antibody, VR22 antibody, catenin alpha 3 antibody, catenin (cadherin associated protein), alpha 3 antibody, CTNNA3 antibody, Ctnna3 antibody

Background:

Synonyms: 4930429L08Rik, 4933408A16, Alpha catenin like protein, Alpha T catenin, Alpha T-catenin, Cadherin associated protein, Cadherin-associated protein, Catenin alpha 3, Catenin alpha-3, Catna3, CTNA3_HUMAN, CTNNA3, MGC26194, MGC75041, OTTHUMP00000019684, OTTMUSP00000028119, OTTMUSP00000028120, RP11-433J16.1, VR22.

Background: The catenins are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer's disease (LOAD) as well as to dilated cardiomyopathy.