Retinoblastoma Protein (Rb) antibody (Cleavage Site)
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- Target See all Retinoblastoma Protein (Rb) (Rb Protein) Antibodies
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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Binding Specificity
- Cleavage Site
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Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Retinoblastoma Protein (Rb) antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- Recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
- Purification
- Protein G purified
- Immunogen
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A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
Type of Immunogen: Synthetic peptide - Clone
- 172C1094
- Isotype
- IgG1
- Top Product
- Discover our top product Rb Protein Primary Antibody
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anti-Retinoblastoma Protein (Rb Protein) (AA 858-886) antibody
Rb Protein Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer811) antibodyRb Protein Reactivity: Human ELISA, IHC, IF, DB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 586-615) antibodyRb Protein Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer608) antibodyRb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer780) antibodyRb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer788) antibodyRb Protein Reactivity: Human ELISA, IHC, DB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) antibodyRb Protein Reactivity: Human ELISA, IHC Host: Mouse Monoclonal 7E4B8 unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 251-268) antibodyRb Protein Reactivity: Human, Mouse, Rat, Cow, Dog, Monkey, Pig, Bat, Horse WB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (N-Term) antibodyRb Protein Reactivity: Human, Mouse, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (C-Term) antibodyRb Protein Reactivity: Human, Cow, Dog, Pig, Bat, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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Approved: IHC, WB (2 μg/mL)
Not recommended for: IHC-P - Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
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Short term: 4°C
Long term: -70°C.
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- Target
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
- Alternative Name
- RB1 / Retinoblastoma / RB (Rb Protein Products)
- Background
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Name/Gene ID: RB1
Synonyms: RB1, p105-Rb, Osteosarcoma, PRb, Retinoblastoma, Retinoblastoma 1, OSRC, RB, Pp110 - Gene ID
- 5925
- UniProt
- P06400
- Pathways
- Mitotic G1-G1/S Phases
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