BRCA2 antibody (AA 2480-2530)

Catalog No. ABIN2017604

Product Details anti-BRCA2 Antibody

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Binding Specificity: AA 2480-2530

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA2 antibody is un-conjugated

Application: Please inquire

Specificity: BRCA2 Antibody detects endogenous levels of human and mouse BRCA2.

Cross-Reactivity: Mouse (Murine)

Characteristics: BRCA2 Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 2480-2530 of human BRCA2 (Swiss Prot: P51587).

Purification: Immunoaffinity chromatography.

Immunogen: KLH-coupled synthetic peptide within residues 2480-2530 of human BRCA2

Isotype: IgG

Application Details

Comment:

Positive Control: HEK293 and Mouse brain

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Concentration: 0.5 mg/mL

Buffer: Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles.

Storage: 4 °C/-20 °C

Storage Comment: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.

Target Details for BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Alternative Name: BRCA2 (BRCA2 Products)

Synonyms: BRCC2 antibody, BROVCA2 antibody, FACD antibody, FAD antibody, FAD1 antibody, FANCB antibody, FANCD antibody, FANCD1 antibody, GLM3 antibody, PNCA2 antibody, 30169 antibody, BcDNA:SD25109 antibody, CG13583 antibody, CG13584 antibody, CG30169 antibody, Dmel\\CG30169 antibody, brca2 antibody, dmbrca2 antibody, fancd1 antibody, BRCA2 antibody, brcc2 antibody, brovca2 antibody, facd antibody, fad antibody, fad1 antibody, fancb antibody, AI256696 antibody, AW045498 antibody, Fancd1 antibody, RAB163 antibody, BRCA2, DNA repair associated antibody, Breast cancer 2, early onset homolog antibody, breast cancer 2, early onset antibody, BRCA2 antibody, Brca2 antibody, brca2 antibody, LOC584780 antibody

Background: Breast cancer type 2 susceptibility protein (BRCA2) is involved in double-strand break repair and/or homologous recombination. It may participate in S phase checkpoint activation. In addition, It interacts with RAD51 and DSS1 and binds to ubiquitinated FANCD2. It also interacts with PALB2, enabling the recombinational repair and checkpoints functions. Defects in BRCA2 can cause genetic susceptibility to breast cancer (BC), also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).

Molecular Weight: Predicted Band Size: 390 KD
Observed Band Size: 390 KD

UniProt: P51587

Pathways: DNA Damage Repair, M Phase, Maintenance of Protein Location