Glyco Protein G antibody
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- Target
- Glyco Protein G
- Reactivity
- Rabies Virus
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Caprylic Acid Ammonium Sulfate Precipitation
- Immunogen
- Recombinant Rabies virus Glycoprotein G protein
- Isotype
- IgG
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- Application Notes
- Optimal working concentration should be determinde by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 0.03 % Proclin 300, 53 % Glycerol, 0.01 M PBS, pH 7.4
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClinTM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze.
- Storage
- -20 °C/-80 °C
- Storage Comment
- Upon delivery aliquot and store at -20 °C or -80 °C.
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[A DNA Construct That Encodes the Rabies Virus Consensus Glycoprotein with a Proteasome Degradation Signal Induces Antibody Production with IgG2A Subtype Predominance]." in: Molekuliarnaia biologiia, Vol. 52, Issue 3, pp. 527-532, (2018) (PubMed).
: "
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[A DNA Construct That Encodes the Rabies Virus Consensus Glycoprotein with a Proteasome Degradation Signal Induces Antibody Production with IgG2A Subtype Predominance]." in: Molekuliarnaia biologiia, Vol. 52, Issue 3, pp. 527-532, (2018) (PubMed).
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- Target
- Glyco Protein G
- Synonyms
- transmembrane glycoprotein G antibody, RABVgp4 antibody
- Target Type
- Viral Protein
- Background
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Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein G and thereby facilitate rabies virus entry into cells.
Synonyms: G - UniProt
- P03524
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