UBA2 antibody

Catalog No. ABIN1944808

Product Details anti-UBA2 Antibody

Target: UBA2 (SUMO1 Activating Enzyme Subunit 2 (UBA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-UBA2 antibody (ABIN1944808)

Wiemann, Weil, Wellenreuther, Gassenhuber, Glassl, Ansorge, Böcher, Blöcker, Bauersachs, Blum, Lauber, Düsterhöft, Beyer, Köhrer, Strack, Mewes, Ottenwälder, Obermaier, Tampe, Heubner, Wambutt, Korn et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ..." in: Genome research, Vol. 11, Issue 3, pp. 422-35, (2001) (PubMed).

Okuma, Honda, Ichikawa, Tsumagari, Yasuda: "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2." in: Biochemical and biophysical research communications, Vol. 254, Issue 3, pp. 693-8, (1999) (PubMed).

Gong, Li, Millas, Yeh: "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex." in: FEBS letters, Vol. 448, Issue 1, pp. 185-9, (1999) (PubMed).

Target Details for UBA2

Target: UBA2 (SUMO1 Activating Enzyme Subunit 2 (UBA2))

Alternative Name: Uba2 (UBA2 Products)

Synonyms: ATSAE2 antibody, EMB2764 antibody, EMBRYO DEFECTIVE 2764 antibody, F3K23.23 antibody, F3K23_23 antibody, SUMO-ACTIVATING ENZYME 2 antibody, SUMO-activating enzyme 2 antibody, ARX antibody, SAE2 antibody, AA986091 antibody, Arx antibody, Sae2 antibody, UBA1 antibody, Ubl1a2 antibody, Uble1b antibody, sae2 antibody, sae2-B antibody, uba2-a antibody, uba2-b antibody, uble1b-B antibody, sae2b antibody, uble1b antibody, wu:fi17g06 antibody, zgc:66354 antibody, SUMO1 activating enzyme subunit 2 antibody, SUMO-activating enzyme 2 antibody, ubiquitin like modifier activating enzyme 2 antibody, ubiquitin-like modifier activating enzyme 2 antibody, ubiquitin like modifier activating enzyme 2 L homeolog antibody, MICPUN_63834 antibody, MICPUCDRAFT_36729 antibody, SAE2 antibody, UBA2 antibody, Uba2 antibody, uba2.L antibody, uba2 antibody

Background: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Molecular Weight: 71224 Da

Gene ID: 10054

UniProt: Q9UBT2