USP11 antibody (N-Term)

Catalog No. ABIN1944797

Product Details anti-USP11 Antibody

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Binding Specificity: AA 32-300, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP11 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This USP11 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 32-300 amino acids from the N-terminal region of human USP11.

Clone: 1220CT620-193-189

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-USP11 antibody (ABIN1944797)

Yamaguchi, Kimura, Miki, Yoshida: "The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)." in: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 33943-8, (2007) (PubMed).

Schoenfeld, Apgar, Dolios, Wang, Aaronson: "BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage." in: Molecular and cellular biology, Vol. 24, Issue 17, pp. 7444-55, (2004) (PubMed).

Ideguchi, Ueda, Tanaka, Yang, Tsuji, Ohno, Hagiwara, Aoki, Ishigatsubo: "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM." in: The Biochemical journal, Vol. 367, Issue Pt 1, pp. 87-95, (2002) (PubMed).

Swanson, Freund, Ploder, McInnes, Valle: "A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders." in: Human molecular genetics, Vol. 5, Issue 4, pp. 533-8, (1996) (PubMed).

Target Details for USP11

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Alternative Name: USP11 (USP11 Products)

Synonyms: USP11 antibody, DKFZp459L098 antibody, UHX1 antibody, 6230415D12Rik antibody, mKIAA4085 antibody, Uhx1 antibody, ubiquitin specific peptidase 11 antibody, universal stress protein antibody, USP11 antibody, RR_RS19935 antibody, Usp11 antibody

Background: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.

Molecular Weight: 109817

Gene ID: 8237

UniProt: P51784