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MAGED1 antibody (AA 20-224)

MAGED1 Reactivity: Human WB Host: Mouse Monoclonal 1305CT862-157-127 unconjugated
Catalog No. ABIN1944790
  • Target See all MAGED1 Antibodies
    MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))
    Binding Specificity
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-224
    Reactivity
    • 39
    • 15
    • 14
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 32
    • 6
    • 1
    Mouse
    Clonality
    • 35
    • 4
    Monoclonal
    Conjugate
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This MAGED1 antibody is un-conjugated
    Application
    • 25
    • 12
    • 12
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This MAGED1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 20-224 amino acids from the Central region of human MAGED1.
    Clone
    1305CT862-157-127
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MAGED1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Wen, Xue, Qin, Yu, Zhang, Zhao, Gao, Gu, Li: "hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation." in: FEBS letters, Vol. 564, Issue 1-2, pp. 171-6, (2004) (PubMed).

    Salehi, Roux, Kubu, Zeindler, Bhakar, Tannis, Verdi, Barker: "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis." in: Neuron, Vol. 27, Issue 2, pp. 279-88, (2000) (PubMed).

    Põld, Zhou, Chen, Hall, Vescio, Berenson: "Identification of a new, unorthodox member of the MAGE gene family." in: Genomics, Vol. 59, Issue 2, pp. 161-7, (1999) (PubMed).

  • Target
    MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))
    Alternative Name
    MAGED1 (MAGED1 Products)
    Synonyms
    MAGED1 antibody, DLXIN-1 antibody, NRAGE antibody, 2810433C11Rik antibody, 5430405L04Rik antibody, DXBwg1492e antibody, Dlixin antibody, Dlxin-1 antibody, Dlxin1 antibody, MAGE-D1 antibody, mFLJ00163 antibody, Nrage antibody, MAGE family member D1 antibody, melanoma antigen family D, 1 antibody, melanoma antigen, family D, 1 antibody, MAGED1 antibody, Maged1 antibody
    Background
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds NGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate TP53/p53 transcriptional activity and inhibit cell proliferation. Enhances TP53 phosphorylation and accumulation. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
    Molecular Weight
    86161
    Gene ID
    9500
    UniProt
    Q9Y5V3
    Pathways
    Neurotrophin Signaling Pathway
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