This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This TCL1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the Central region of human TCL1A.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
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Virgilio, Narducci, Isobe, Billips, Cooper, Croce, Russo: "Identification of the TCL1 gene involved in T-cell malignancies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 26, pp. 12530-4, (1995) (PubMed).
Fu, Virgilio, Narducci, Facchiano, Russo, Croce: "Characterization and localization of the TCL-1 oncogene product." in: Cancer research, Vol. 54, Issue 24, pp. 6297-301, (1995) (PubMed).
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.