CSNK2A1/CK II alpha antibody (AA 162-195)

Catalog No. ABIN1944758

Product Details anti-CSNK2A1/CK II alpha Antibody

Target: CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))

Binding Specificity: AA 162-195

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSNK2A1/CK II alpha antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, C, M, Rb, Rat, X, D

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CSNK2A1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the Central region of human CSNK2A1.

Clone: RB48212

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CSNK2A1/CK II alpha antibody (ABIN1944758)

Devilat, Carvallo: "Structure and sequence of an intronless gene for human casein kinase II-alpha subunit." in: FEBS letters, Vol. 316, Issue 2, pp. 114-8, (1993) (PubMed).

Lozeman, Litchfield, Piening, Takio, Walsh, Krebs: "Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II." in: Biochemistry, Vol. 29, Issue 36, pp. 8436-47, (1991) (PubMed).

Target Details for CSNK2A1/CK II alpha

Target: CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))

Alternative Name: CSNK2A1 (CSNK2A1 Products)

Synonyms: CK2A2 antibody, CSNK2A1 antibody, CK2A1 antibody, CKII antibody, CSNK2A3 antibody, CK2A antibody, Ck2a antibody, BmCK2a antibody, wu:fi38e04 antibody, wu:fi38h03 antibody, csnk2a1 antibody, CK-II antibody, CK2 antibody, Ckiialpha antibody, Csnk2a1-rs4 antibody, ck2a1 antibody, casein kinase 2 alpha 2 antibody, casein kinase 2 alpha 1 antibody, casein kinase 2 alpha subunit antibody, casein kinase 2, alpha 1 polypeptide antibody, CK2 protein kinase alpha 2 antibody, casein kinase II alpha subunit antibody, Casein kinase II alpha subunit antibody, casein kinase 2, alpha 1 polypeptide S homeolog antibody, CSNK2A2 antibody, CSNK2A1 antibody, ck2a antibody, Ck2a antibody, csnk2a1 antibody, cka2 antibody, Ckiialpha antibody, CK2A1 antibody, Csnk2a1 antibody, csnk2a1.S antibody

Background: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin- mediated degradation.

Molecular Weight: 45144

Gene ID: 1457

UniProt: P68400

Pathways: SARS-CoV-2 Protein Interactome