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UIMC1 antibody (C-Term)

UIMC1 Reactivity: Human WB, FACS Host: Rabbit Polyclonal RB48354 unconjugated
Catalog No. ABIN1944736
  • Target See all UIMC1 Antibodies
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Binding Specificity
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 567-601, C-Term
    Reactivity
    • 31
    • 8
    • 5
    Human
    Host
    • 28
    • 2
    • 1
    Rabbit
    Clonality
    • 31
    Polyclonal
    Conjugate
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UIMC1 antibody is un-conjugated
    Application
    • 18
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1.
    Clone
    RB48354
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Yan, Kim, Jetten: "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 32379-88, (2002) (PubMed).

  • Target
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Alternative Name
    UIMC1 (UIMC1 Products)
    Synonyms
    UIMC1 antibody, RAP80 antibody, X2HRIP110 antibody, 9430016E08Rik antibody, D330018D10Rik antibody, D630032M02Rik antibody, RIP110 antibody, Rxrip110 antibody, RGD1307009 antibody, ubiquitin interaction motif containing 1 antibody, UIMC1 antibody, Uimc1 antibody
    Background
    Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
    Molecular Weight
    79727
    Gene ID
    51720
    UniProt
    Q96RL1
    Pathways
    DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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