UIMC1 antibody (C-Term)

Catalog No. ABIN1944736

Product Details anti-UIMC1 Antibody

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Binding Specificity: AA 567-601, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UIMC1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1.

Clone: RB48354

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-UIMC1 antibody (ABIN1944736)

Yan, Kim, Jetten: "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 32379-88, (2002) (PubMed).

Target Details for UIMC1

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Alternative Name: UIMC1 (UIMC1 Products)

Synonyms: UIMC1 antibody, RAP80 antibody, X2HRIP110 antibody, 9430016E08Rik antibody, D330018D10Rik antibody, D630032M02Rik antibody, RIP110 antibody, Rxrip110 antibody, RGD1307009 antibody, ubiquitin interaction motif containing 1 antibody, UIMC1 antibody, Uimc1 antibody

Background: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Molecular Weight: 79727

Gene ID: 51720

UniProt: Q96RL1

Pathways: DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus