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CD300a antibody

CD300A Reactivity: Human FACS, WB Host: Mouse Monoclonal MEM-260 unconjugated
Catalog No. ABIN192408
  • Target See all CD300a (CD300A) Antibodies
    CD300a (CD300A)
    Reactivity
    • 28
    • 7
    • 1
    Human
    Host
    • 15
    • 13
    • 5
    Mouse
    Clonality
    • 17
    • 16
    Monoclonal
    Conjugate
    • 16
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    This CD300a antibody is un-conjugated
    Application
    • 19
    • 13
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB)
    Specificity
    The antibody MEM-260 reacts with an extracellular epitope of CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25 % of circulating T cells and 15 % of circulating B cells.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    HPB human acute lymphoid leukemia cell line
    Clone
    MEM-260
    Isotype
    IgG1
    Top Product
    Discover our top product CD300A Primary Antibody
  • Application Notes
    Flow cytometry: Recommended dilution: 2 μg/mL.
    Western blotting: Positive material: HPB cell line, negative material: JURKAT human cell line, RAJI human cell line, non-reducing conditions.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    CD300a (CD300A)
    Alternative Name
    CD300a (CD300A Products)
    Background
    CD300a molecule,CD300a (CMRF-35H, IRp60) is a non-MHC-specific inhibitory receptor of immunoglobulin superfamily, which contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that associate with SH2-containing phosphatases SHP-1 and SHP-2. CD300a is expressed on many cell types including T cells, NK cells, neutrophils, eosinophils or mast cells. Its triggering inhibits activating signals such as those of IL5, GM-CSF or eotaxin, as well as supresses mast cell degranulation or NK cell cytotoxic activity.,IRC, CLM-8, IGSF12, CMRF35H
    Gene ID
    11314
    UniProt
    Q9UGN4
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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