PLSCR1 antibody

Catalog No. ABIN192390

Product Details anti-PLSCR1 Antibody

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLSCR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Specificity: The antibody 13A6 [TEC-23] binds to an intracellular epitope of rat Phospholipid Scramblase 1 (PLSCR1), an 37-49 kDa protein, accelerating bidirectional movement of plasma membrane phospholipids under conditions of elevated calcium.

Cross-Reactivity (Details): Rat

Immunogen: Pooled lipid raft fraction isolated from RBL-2H3 cells

Clone: 13A6 [TEC-23]

Isotype: IgG2a

Application Details

Application Notes: Western blotting: Recommended dilution: 1 μg/mL, positive control: RBL (rat basophilic leukemia) cell line, both reducing and non-reducing conditions.
Flow cytometry: Intracellular staining.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilized with 15 mM sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.
Avoid prolonged exposure to light.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-PLSCR1 antibody (ABIN192390)

Smrz, Lebduska, Dráberová, Korb, Dráber: "Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis." in: The Journal of biological chemistry, Vol. 283, Issue 16, pp. 10904-18, (2008) (PubMed).

Target Details for PLSCR1

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Alternative Name: PLSCR1 (PLSCR1 Products)

Synonyms: mmtra1b antibody, MGC84969 antibody, PLSCR1 antibody, MGC148322 antibody, MMTRA1B antibody, MmTRA1a antibody, MmTRA1b antibody, Nor1 antibody, Tra1 antibody, Tra1a antibody, Tra1b antibody, Tras1 antibody, Tras2 antibody, PLSCR2 antibody, phospholipid scramblase 1 L homeolog antibody, phospholipid scramblase 1 antibody, plscr1.L antibody, PLS1 antibody, PVX_111580 antibody, PLSCR1 antibody, plscr1 antibody, Plscr1 antibody, LOC100712949 antibody, PLSCR2 antibody, LOC100341366 antibody, LOC611500 antibody

Background: Phospholipid scramblase 1,PLSCR1 (phospholipid scramblase 1) is a multiply palmitoylated endofacial plasma membrane protein containing several SH3 and WW domain binding motives. In the plasma membrane, PLSCR1 plays a role in transbilayer lipid redistributions and signal transduction. Nonpalmitoylated PLSCR1, however, is able to be transported into the nucleus and bind DNA. PLSCR1 potentiates the antiviral activity of interferon and its expression is highly induced by interferons and growth factors.,PL scramblase 1, phospholipid scramblase 1

Gene ID: 117540

UniProt: P58195

Pathways: Cellular Response to Molecule of Bacterial Origin