NPPB antibody (N-Term)

Catalog No. ABIN191916

Product Details anti-NPPB Antibody

Target: NPPB (Natriuretic Peptides B (NPPB))

Binding Specificity: AA 1-21, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NPPB antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects Synthetic Human proBNP (aa 1-21), Human proBNP

Characteristics: Synonyms: NPPB, Brain natriuretic peptide, BNP, proBNP, Gamma-brain natriuretic peptide

Purification: Protein A Chromatography

Immunogen: Synthetic human pro-BNP (aa 1-21) poly Lysin conjugatedAA Sequence: HPLGSPGSASDLETSGLQEQR

Clone: 21-06-06

Isotype: IgG2a

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in aqua bidest to 1 mg/mL

Buffer: 200 mM Sodium Citrat / Tris, 500 mM NaCl buffer pH 7.5 containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for NPPB

Target: NPPB (Natriuretic Peptides B (NPPB))

Alternative Name: Natriuretic Peptides B (NPPB Products)

Background: In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa "signal" peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.Synonyms: BNP, Brain natriuretic peptide, Gamma-brain natriuretic peptide, NPPB, proBNP

Gene ID: 4879

UniProt: P16860

Pathways: Hormone Activity