CAMK2A
Reactivity: Human
WB, ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Immunoblotting: Use at 1-5 μg/mL. A band of ~50-60 kDa is detected. Immunohistochemistry: use at 1-10 μg/mL. These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Restrictions
For Research Use only
Format
Liquid
Reconstitution
Dilute in PBS or medium that is identical to that used in the assay system.
Concentration
Lot specific
Buffer
PBS, 50 % glycerol, 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
This antibody is stable for at least one (1) year at -20°C.
Target
CAMK2A
(Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))
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Background
Calcium/calmodulin-dependent protein kinase type II subunit α,Calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CaMKII has 28 different isoforms that derive from the alpha, beta, gamma, and delta genes. Misregulation of CaMKII is linked to Alzheimer's disease, Angelman syndrome, and heart arrhythmia.,CaM kinase II subunit α, CaMK-II subunit α, EC 2.7.11.17