LEMD3 antibody (C-Term)

Catalog No. ABIN1887347

Product Details anti-LEMD3 Antibody

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEMD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): At least three isoforms of LEMD3 are known to exist, this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2

Purification: Affinity chromatography purified via peptide column

Immunogen: LEMD3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LEMD3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for LEMD3

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Alternative Name: LEMD3 (LEMD3 Products)

Synonyms: MAN1 antibody, AI316861 antibody, Man1 antibody, im:7158446 antibody, wu:fb34b12 antibody, si:dkey-6a5.6 antibody, RGD1561001 antibody, man1 antibody, sane antibody, xman1 antibody, lemd3 antibody, LEM domain containing 3 antibody, LEM domain containing 3 S homeolog antibody, LEMD3 antibody, Lemd3 antibody, lemd3 antibody, lemd3.S antibody

Background: LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis.LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.
Synonyms: LEM domain containing 3, MAN1

NCBI Accession: NP_055134