GP1BB antibody (AA 56-118)

Catalog No. ABIN1886554

Product Details anti-GP1BB Antibody

Target: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Binding Specificity: AA 56-118

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GP1BB antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 56 and 118 of Human GP1BB

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for GP1BB

Target: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Alternative Name: CD42c (GP1BB Products)

Synonyms: BDPLT1 antibody, BS antibody, CD42C antibody, GPIBB antibody, glycoprotein Ib (platelet), beta polypeptide antibody, glycoprotein Ib platelet beta subunit antibody, glycoprotein Ib, beta polypeptide antibody, GP1BB antibody, Gp1bb antibody

Background: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain.It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation.GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain.Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder.The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes.A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described, however, the authenticity of this product has been questioned.Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene.In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene.[provided by RefSeq]

Molecular Weight: 22 kDa

Gene ID: 2812

NCBI Accession: NP_000398, NM_000407