Phospholamban antibody (N-Term)

Catalog No. ABIN1882182

Product Details anti-Phospholamban Antibody

Target: Phospholamban (PLN)

Binding Specificity: AA 1-22, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholamban antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M, Pig, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.

Clone: RB44799

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Phospholamban antibody (ABIN1882182)

Kaliman, Catalucci, Lam, Kondo, Gutiérrez, Reddy, Palacín, Zorzano, Chien, Ruiz-Lozano: "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 8016-21, (2005) (PubMed).

Minamisawa, Sato, Tatsuguchi, Fujino, Imamura, Uetsuka, Nakazawa, Matsuoka: "Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy." in: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 1-4, (2003) (PubMed).

McTiernan, Frye, Lemster, Kinder, Ogletree-Hughes, Moravec, Feldman: "The human phospholamban gene: structure and expression." in: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 679-92, (1999) (PubMed).

Fujii, Zarain-Herzberg, Willard, Tada, MacLennan: "Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11669-75, (1991) (PubMed).

Target Details for Phospholamban

Target: Phospholamban (PLN)

Alternative Name: PLN (PLN Products)

Synonyms: LOC100226261 antibody, plb antibody, cmd1p antibody, CMD1P antibody, CMH18 antibody, PLB antibody, Plb antibody, Plm antibody, phospholamban antibody, PLN antibody, pln antibody, Pln antibody

Background: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Molecular Weight: 6109

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity