DAPK2 antibody (N-Term)

Catalog No. ABIN1882166

Product Details anti-DAPK2 Antibody

Target: DAPK2 (Death-Associated Protein Kinase 2 (DAPK2))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAPK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This DAPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DAPK2.

Clone: RB3053

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:2000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DAPK2 antibody (ABIN1882166)

Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: "Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis." in: The Journal of biological chemistry, Vol. 290, Issue 32, pp. 19967-75, (2015) (PubMed).

Karur, Lowell, Besmer, Agosti, Wojchowski: "Lyn kinase promotes erythroblast expansion and late-stage development." in: Blood, Vol. 108, Issue 5, pp. 1524-32, (2006) (PubMed).

Satoh, Toyota, Itoh, Kikuchi, Obata, Sasaki, Suzuki, Yawata, Kusano, Fujita, Hosokawa, Yanagihara, Tokino, Imai: "DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers." in: British journal of cancer, Vol. 86, Issue 11, pp. 1817-23, (2002) (PubMed).

Chan, Chan, Tang, Tong, Lo, Lee, Cheung, Wong, Chan, Lai, To: "Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 8, Issue 2, pp. 464-70, (2002) (PubMed).

Wong, Chang, Tang, Wei, Kwong, Sham, Yuen, Kwong: "High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 8, Issue 2, pp. 433-7, (2002) (PubMed).

Shani, Henis-Korenblit, Jona, Gileadi, Eisenstein, Ziv, Admon, Kimchi: "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding." in: The EMBO journal, Vol. 20, Issue 5, pp. 1099-113, (2001) (PubMed).

Target Details for DAPK2

Target: DAPK2 (Death-Associated Protein Kinase 2 (DAPK2))

Alternative Name: DAPK2 (DAPK2 Products)

Synonyms: drp1 antibody, drp-1 antibody, DAPK2 antibody, dapk2 antibody, DRP-1 antibody, DRP1 antibody, death-associated protein kinase 2 L homeolog antibody, death associated protein kinase 2 antibody, death-associated protein kinase 2b antibody, death-associated protein kinase 2 antibody, dapk2.L antibody, DAPK2 antibody, dapk2b antibody, dapk2 antibody, Dapk2 antibody

Background: DAPK2 belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.

Molecular Weight: 42898

NCBI Accession: NP_055141

UniProt: Q9UIK4