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Aurora A antibody (C-Term)

AURKA Reactivity: Human WB, IF, FACS Host: Rabbit Polyclonal RB6834 unconjugated
Catalog No. ABIN1882163
  • Target See all Aurora A (AURKA) Antibodies
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Binding Specificity
    • 22
    • 16
    • 8
    • 8
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 364-392, C-Term
    Reactivity
    • 109
    • 71
    • 39
    • 21
    • 18
    • 14
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    Human
    Host
    • 110
    • 16
    • 1
    Rabbit
    Clonality
    • 104
    • 22
    Polyclonal
    Conjugate
    • 73
    • 9
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Aurora A antibody is un-conjugated
    Application
    • 93
    • 52
    • 32
    • 21
    • 15
    • 11
    • 11
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Aurora-A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-392 amino acids from the C-terminal region of human Aurora-A.
    Clone
    RB6834
    Isotype
    Ig Fraction
    Top Product
    Discover our top product AURKA Primary Antibody
  • Application Notes
    IF: 1:10~50. WB: 1:1000. WB: 1:1000. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Nakamura, Hirano, Okinaka, Takemura, Yokota, Ono, Shigeno, Shibata, Fujisawa, Ohnishi: "The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia." in: Carcinogenesis, Vol. 31, Issue 11, pp. 2012-21, (2010) (PubMed).

    Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

    Tanaka, Ueda, Kanamori, Ideguchi, Yang, Kitajima, Ishigatsubo: "Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1." in: The Journal of biological chemistry, Vol. 277, Issue 12, pp. 10719-26, (2002) (PubMed).

    Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

    Nigg: "Mitotic kinases as regulators of cell division and its checkpoints." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 1, pp. 21-32, (2001) (PubMed).

    Shindo, Nakano, Kuroyanagi, Shirasawa, Mihara, Gilbert, Jenkins, Copeland, Yagita, Okumura: "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2." in: Biochemical and biophysical research communications, Vol. 244, Issue 1, pp. 285-92, (1998) (PubMed).

  • Target
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Alternative Name
    Aurora-A (AURKA Products)
    Synonyms
    AIK antibody, ARK1 antibody, AURA antibody, AURORA2 antibody, BTAK antibody, PPP1R47 antibody, STK15 antibody, STK6 antibody, STK7 antibody, AIRK1 antibody, AU019385 antibody, AW539821 antibody, Ark1 antibody, Aurora-A antibody, Ayk1 antibody, IAK antibody, IAK1 antibody, Stk6 antibody, 87A7-9/2 antibody, Aur-A antibody, AurA antibody, CG3068 antibody, Dmel\\CG3068 antibody, aur-A antibody, aurA antibody, ck10 antibody, ck[10] antibody, l(3)87Ac antibody, l(3)ck10 antibody, ARK-1 antibody, Eg2 antibody, aik antibody, ark1 antibody, aur-a antibody, aura antibody, aurka-a antibody, aurora2 antibody, btak antibody, stk15 antibody, stk6 antibody, stk7 antibody, pEg2 antibody, wu:fb37c10 antibody, wu:fc02c02 antibody, zgc:100912 antibody, AURKA antibody, aurka antibody, aurora kinase A antibody, aurora A antibody, aurora kinase A L homeolog antibody, hypothetical protein antibody, aurora kinase A S homeolog antibody, AURKA antibody, Aurka antibody, aurA antibody, aurka.L antibody, aurka antibody, Aurora-A antibody, aurka.S antibody
    Background
    Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Auroria kinase A may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. It may be involved in microtubule formation and/or stabilization. This protein has also been postulated to play a key role during tumor development and progression. Aurora kinase A localizes on centrosomes in interphase cells and at each spindle pole in mitosis. It is highly expressed in testis, weakly in skeletal muscle, thymus and spleen, and also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly afterward. Defects in Aurora kinase A are responsible for numerical centrosome aberrations including aneuploidy.
    Molecular Weight
    45809
    NCBI Accession
    NP_003591, NP_940835, NP_940836, NP_940837, NP_940838, NP_940839
    UniProt
    O14965
    Pathways
    Cell Division Cycle, Asymmetric Protein Localization
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