UVRAG antibody (C-Term)

Catalog No. ABIN1882151

Product Details anti-UVRAG Antibody

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Binding Specificity: AA 540-569, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UVRAG antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human UVRAG.

Clone: RB13045

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-UVRAG antibody (ABIN1882151)

Wei: "Autophagic induction of amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cells." in: Neural regeneration research, Vol. 9, Issue 1, pp. 16-24, (2014) (PubMed).

Bodemann, Orvedahl, Cheng, Ram, Ou, Formstecher, Maiti, Hazelett, Wauson, Balakireva, Camonis, Yeaman, Levine, White: "RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly." in: Cell, Vol. 144, Issue 2, pp. 253-67, (2011) (PubMed).

Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." in: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, (2006) (PubMed).

Vogt, Affara, Davey, Hammer, Jobling, Lau, Mitchell, Schempp, Tyler-Smith, Williams, Yen, Rappold: "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997." in: Cytogenetics and cell genetics, Vol. 79, Issue 1-2, pp. 1-20, (1998) (PubMed).

Target Details for UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Alternative Name: UVRAG (UVRAG Products)

Background: UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving the UVAG gene are associated with left-right axis malformation and mutations in the gene have been associated with colon cancer.

Molecular Weight: 78151

NCBI Accession: NP_003360

UniProt: Q9P2Y5