TK2 antibody (N-Term)
TK2
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
RB5434
unconjugated
1 image
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- Target See all TK2 Antibodies
- TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
- Binding Specificity
- AA 8-38, N-Term
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
- Clone
- RB5434
- Isotype
- Ig Fraction
-
- Application Notes
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
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- Target
- TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
- Abstract
- TK2 Products
- Synonyms
- MTDPS2 antibody, MTTK antibody, AU024611 antibody, mt-TK antibody, tk2 antibody, zgc:100948 antibody, thymidine kinase 2, mitochondrial antibody, thymidine kinase 2, mitochondrial S homeolog antibody, TK2 antibody, Tk2 antibody, tk2.S antibody, tk2 antibody
- Background
- Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
- Molecular Weight
- 31005
- NCBI Accession
- NP_001166114, NP_001166115, NP_001258864, NP_004605
- UniProt
- O00142
- Pathways
- Mitotic G1-G1/S Phases
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