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TK2 antibody (N-Term)

TK2 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB5434 unconjugated
Catalog No. ABIN1882141
  • Target See all TK2 Antibodies
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    Binding Specificity
    AA 8-38, N-Term
    Reactivity
    Human, Mouse
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
    Clone
    RB5434
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    Abstract
    TK2 Products
    Synonyms
    MTDPS2 antibody, MTTK antibody, AU024611 antibody, mt-TK antibody, tk2 antibody, zgc:100948 antibody, thymidine kinase 2, mitochondrial antibody, thymidine kinase 2, mitochondrial S homeolog antibody, TK2 antibody, Tk2 antibody, tk2.S antibody, tk2 antibody
    Background
    Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
    Molecular Weight
    31005
    NCBI Accession
    NP_001166114, NP_001166115, NP_001258864, NP_004605
    UniProt
    O00142
    Pathways
    Mitotic G1-G1/S Phases
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