PAPSS1 antibody (N-Term)

Catalog No. ABIN1882107

Product Details anti-PAPSS1 Antibody

Target: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAPSS1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PAPSS1.

Clone: RB5122

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PAPSS1 antibody (ABIN1882107)

Gillies, Lee, Long, Ktistakis, Pyne, Pyne: "The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division." in: Cellular signalling, Vol. 21, Issue 5, pp. 675-84, (2009) (PubMed).

Venkatachalam: "Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency." in: IUBMB life, Vol. 55, Issue 1, pp. 1-11, (2003) (PubMed).

Xu, Otterness, Freimuth, Carlini, Wood, Mitchell, Moon, Kim, Xu, Siciliano, Weinshilboum: "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization." in: Biochemical and biophysical research communications, Vol. 268, Issue 2, pp. 437-44, (2000) (PubMed).

Venkatachalam, Akita, Strott: "Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains." in: The Journal of biological chemistry, Vol. 273, Issue 30, pp. 19311-20, (1998) (PubMed).

Faiyaz ul Haque, King, Krakow, Cantor, Rusiniak, Swank, Superti-Furga, Haque, Abbas, Ahmad, Ahmad, Cohn: "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse." in: Nature genetics, Vol. 20, Issue 2, pp. 157-62, (1998) (PubMed).

Girard, Baekkevold, Amalric: "Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 12, Issue 7, pp. 603-12, (1998) (PubMed).

Target Details for PAPSS1

Target: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Alternative Name: PAPSS1 (PAPSS1 Products)

Synonyms: ATPSK1 antibody, PAPSS antibody, SK1 antibody, AI325286 antibody, Asapk antibody, papss1 antibody, MGC82588 antibody, atpsk1 antibody, papss antibody, sk1 antibody, PAPSS1 antibody, wu:fc43e12 antibody, zgc:194984 antibody, zgc:194985 antibody, CG8363 antibody, DmPAPSS antibody, Dmel\\CG8363 antibody, PAPS antibody, Paps antibody, l(3)76BDn antibody, paps antibody, 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antibody, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antibody, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antibody, PAPS synthetase antibody, PAPSS1 antibody, Papss1 antibody, papss1 antibody, papss1.L antibody, LOC100543301 antibody, LOC100637112 antibody, Papss antibody

Background: Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.

Molecular Weight: 70833

NCBI Accession: NP_005434

UniProt: O43252

Pathways: Glycosaminoglycan Metabolic Process, Ribonucleoside Biosynthetic Process