FKBP1A antibody (C-Term)

Catalog No. ABIN1882082

Product Details anti-FKBP1A Antibody

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Binding Specificity: AA 55-83, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP1A antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, Rb

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This FKBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the C-terminal region of human FKBP1A.

Clone: RB19307

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FKBP1A antibody (ABIN1882082)

Gerard, Debyser, Desender, Baert, Brandt, Baekelandt, Engelborghs: "FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T." in: Journal of neurochemistry, Vol. 106, Issue 1, pp. 121-33, (2008) (PubMed).

Shor, Zhang, Toral-Barza, Lucas, Abraham, Gibbons, Yu: "A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis." in: Cancer research, Vol. 68, Issue 8, pp. 2934-43, (2008) (PubMed).

Target Details for FKBP1A

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Alternative Name: FKBP1A (FKBP1A Products)

Synonyms: 12kDa antibody, FKBP12 antibody, FKBP12-T1 antibody, FKBP12-T2 antibody, Fkbp antibody, Fkbp1 antibody, mFKBP1 antibody, mFKBP12 antibody, FKBP-12 antibody, FKBP-1A antibody, FKBP1 antibody, Rotamase antibody, Fkbp12 antibody, ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12 antibody, ATFKBP12 antibody, FK506-binding protein 12 antibody, IMMUNOPHILIN antibody, MSJ1.19 antibody, MSJ1_19 antibody, PKC12 antibody, PKCI2 antibody, PPIASE antibody, FKBP1B antibody, Fkbp2 antibody, fj02g10 antibody, zgc:73373 antibody, wu:fj02g10 antibody, FKBP1A antibody, Bmfkbp13 antibody, zgc:103752 antibody, FK506 binding protein 1a antibody, FK506 binding protein 1A antibody, FK506-binding protein antibody, FK506-binding protein 12 antibody, FK506 binding protein 1Aa antibody, FK506 binding protein 1C antibody, FK506-binding protein 59 antibody, FK506 binding protein like antibody, FK506 binding protein 1A L homeolog antibody, FK506 binding protein 1Ab antibody, Fkbp1a antibody, FKBP1A antibody, Fkbp12 antibody, FKBP12 antibody, fkbp1aa antibody, FKBP1C antibody, EHI_180160 antibody, LOC5573443 antibody, Fkbp13 antibody, FKBPL antibody, fkbp1a.L antibody, fkbp1ab antibody

Background: FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

Molecular Weight: 11951

NCBI Accession: NP_000792, NP_463460

UniProt: P62942

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process