PA2G4 antibody (C-Term)

Catalog No. ABIN1882075

Product Details anti-PA2G4 Antibody

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Binding Specificity: AA 322-350, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PA2G4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Predicted Reactivity: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the C-terminal region of human EBP1.

Clone: RB19220

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PA2G4 antibody (ABIN1882075)

Zhang, Linn, Liu, Melamed, Tavora, Young, Burger, Hamburger: "EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance." in: Molecular cancer therapeutics, Vol. 7, Issue 10, pp. 3176-86, (2008) (PubMed).

Target Details for PA2G4

Target: PA2G4 (Proliferation-Associated 2G4, 38kDa (PA2G4))

Alternative Name: EBP1 (PA2G4 Products)

Background: PA2G4 is an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells.

Molecular Weight: 43787

NCBI Accession: NP_006182

UniProt: Q9UQ80

Pathways: Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades