BBS4 antibody (AA 1-240)

Catalog No. ABIN1882046

Product Details anti-BBS4 Antibody

Target: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Binding Specificity: AA 1-240

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This BBS4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This BBS4 antibody is generated from a mice immunized with a recombinant protein between 1-240 amino acids from human BBS4.

Clone: 1292CT845-130-218

Isotype: IgG1

Application Details

Application Notes: IHC: 1:250. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BBS4 antibody (ABIN1882046)

Badano, Leitch, Ansley, May-Simera, Lawson, Lewis, Beales, Dietz, Fisher, Katsanis: "Dissection of epistasis in oligogenic Bardet-Biedl syndrome." in: Nature, Vol. 439, Issue 7074, pp. 326-30, (2006) (PubMed).

Target Details for BBS4

Target: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Alternative Name: BBS4 (BBS4 Products)

Synonyms: CG13232 antibody, Dmel\\CG13232 antibody, zgc:152964 antibody, AW537059 antibody, AW742241 antibody, D9Ertd464e antibody, Bardet-Biedl syndrome 4 antibody, bardet-biedl syndrome 4 antibody, Bardet-Biedl syndrome 4 (human) antibody, BBS4 antibody, bbs4 antibody, Bbs4 antibody

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.

Molecular Weight: 58282

UniProt: Q96RK4

Pathways: Hedgehog Signaling, Tube Formation, Maintenance of Protein Location