This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ZNF148 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human ZNF148.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Udelhoven, Pasieka, Leeser, Krone, Schubert: "Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter." in: The Journal of endocrinology, Vol. 204, Issue 2, pp. 199-208, (2010) (PubMed).
Chen, Chan, Bai, Fung, Tessier, To, Merchant, Lai: "ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest." in: Cancer letters, Vol. 283, Issue 1, pp. 52-8, (2009) (PubMed).
Feng, Wang, Xu, Pan, Zhu, Liang, Huang, Lu: "The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence." in: The FEBS journal, Vol. 276, Issue 15, pp. 4197-206, (2009) (PubMed).
Borghaei, Gorski, Javadi: "NF-kappaB and ZBP-89 regulate MMP-3 expression via a polymorphic site in the promoter." in: Biochemical and biophysical research communications, Vol. 382, Issue 2, pp. 269-73, (2009) (PubMed).
Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).
ZNF148 is involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.