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TXN antibody (C-Term)

TXN Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB42816 unconjugated
Catalog No. ABIN1881960
  • Target See all TXN Antibodies
    TXN (Thioredoxin (TXN))
    Binding Specificity
    • 20
    • 6
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 66-94, C-Term
    Reactivity
    • 75
    • 26
    • 21
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 80
    • 16
    Rabbit
    Clonality
    • 71
    • 25
    Polyclonal
    Conjugate
    • 41
    • 16
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    This TXN antibody is un-conjugated
    Application
    • 64
    • 35
    • 29
    • 13
    • 12
    • 8
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, M, Pig, Rb, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This TXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human TXN.
    Clone
    RB42816
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TXN Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Zheng, Ma, Sun, Yin, Lin, Liu, Xu, Zeng: "Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity." in: Redox biology, Vol. 14, pp. 237-249, (2018) (PubMed).

  • Target
    TXN (Thioredoxin (TXN))
    Alternative Name
    TXN (TXN Products)
    Background
    Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
    Molecular Weight
    11737
    NCBI Accession
    NP_001231867, NP_003320
    UniProt
    P10599
    Pathways
    Carbohydrate Homeostasis, Cell RedoxHomeostasis
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