TNNC2 antibody (C-Term)

Catalog No. ABIN1881894

Product Details anti-TNNC2 Antibody

Target: TNNC2 (Fast Skeletal Troponin C (TNNC2))

Binding Specificity: AA 97-126, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNNC2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TNNC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the C-terminal region of human TNNC2.

Clone: RB32470

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TNNC2 antibody (ABIN1881894)

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Robinson, Lipscomb, Preston, Altin, Watkins, Ashley, Redwood: "Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 21, Issue 3, pp. 896-905, (2007) (PubMed).

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Vassylyev, Takeda, Wakatsuki, Maeda, Maéda: "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 4847-52, (1998) (PubMed).

Target Details for TNNC2

Target: TNNC2 (Fast Skeletal Troponin C (TNNC2))

Alternative Name: TNNC2 (TNNC2 Products)

Synonyms: Tncs antibody, STNC antibody, tnnc antibody, wu:fb39a12 antibody, tnnc2 antibody, troponin C2, fast skeletal type antibody, troponin C2, fast antibody, troponin C type 2 (fast) antibody, fast skeletal troponin C beta antibody, troponin C type 2 (fast) L homeolog antibody, TNNC2 antibody, Tnnc2 antibody, tnnc2 antibody, tnnc2.L antibody

Background: Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.

Molecular Weight: 18122

NCBI Accession: NP_003270

UniProt: P02585