TIPIN antibody (N-Term)

Catalog No. ABIN1881887

Product Details anti-TIPIN Antibody

Target: TIPIN (TIMELESS Interacting Protein (TIPIN))

Binding Specificity: AA 227-254, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIPIN antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TIPIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the N-terminal region of human TIPIN.

Clone: RB40607

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TIPIN antibody (ABIN1881887)

Kemp, Akan, Yilmaz, Grillo, Smith-Roe, Kang, Cordeiro-Stone, Kaufmann, Abraham, Sancar, Unsal-Kaçmaz: "Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16562-71, (2010) (PubMed).

Leman, Noguchi, Lee, Noguchi: "Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion." in: Journal of cell science, Vol. 123, Issue Pt 5, pp. 660-70, (2010) (PubMed).

Gotter, Suppa, Emanuel: "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors." in: Journal of molecular biology, Vol. 366, Issue 1, pp. 36-52, (2007) (PubMed).

Target Details for TIPIN

Target: TIPIN (TIMELESS Interacting Protein (TIPIN))

Alternative Name: TIPIN (TIPIN Products)

Synonyms: 1110005A05Rik antibody, 1110018P21Rik antibody, RGD1564084 antibody, MGC82649 antibody, zgc:91928 antibody, tipin antibody, TIMELESS interacting protein antibody, timeless interacting protein antibody, timeless interacting protein S homeolog antibody, timeless interacting protein L homeolog antibody, TIPIN antibody, Tipin antibody, tipin.S antibody, tipin antibody, tipin.L antibody

Background: Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.

Molecular Weight: 34555

NCBI Accession: NP_060328

UniProt: Q9BVW5