TFEC antibody (AA 179-205)

Catalog No. ABIN1881878

Product Details anti-TFEC Antibody

Target: TFEC (Transcription Factor EC (TFEC))

Binding Specificity: AA 179-205

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFEC antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: C, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TFEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-205 amino acids from the Central region of human TFEC.

Clone: RB40605

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TFEC antibody (ABIN1881878)

Mansky, Sulzbacher, Purdom, Nelsen, Hume, Rehli, Ostrowski: "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter." in: Journal of leukocyte biology, Vol. 71, Issue 2, pp. 304-10, (2002) (PubMed).

Chung, Kim, Kawamoto: "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells." in: Biochemistry, Vol. 40, Issue 30, pp. 8887-97, (2001) (PubMed).

Steingrímsson, Tessarollo, Reid, Jenkins, Copeland: "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization." in: Development (Cambridge, England), Vol. 125, Issue 23, pp. 4607-16, (1999) (PubMed).

Target Details for TFEC

Target: TFEC (Transcription Factor EC (TFEC))

Alternative Name: TFEC (TFEC Products)

Synonyms: si:ch211-238e6.5 antibody, TFEC antibody, TCFEC antibody, TFE-C antibody, TFEC-L antibody, TFECL antibody, bHLHe34 antibody, hTFEC-L antibody, BB107417 antibody, Tcfec antibody, transcription factor EC antibody, tfec antibody, TFEC antibody, Tfec antibody

Background: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo-or heterodimeric form.

Molecular Weight: 38788

NCBI Accession: NP_001018068, NP_001231512, NP_036384

UniProt: O14948