SUB1 antibody (AA 18-47)

Catalog No. ABIN1881856

Product Details anti-SUB1 Antibody

Target: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Binding Specificity: AA 18-47

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUB1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the Central region of human SUB1.

Clone: RB40953

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SUB1 antibody (ABIN1881856)

Das, Gadad, Kundu: "Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST." in: Journal of molecular biology, Vol. 397, Issue 1, pp. 1-12, (2010) (PubMed).

Rajagopalan, Andreeva, Teufel, Freund, Fersht: "Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21728-37, (2009) (PubMed).

Mortusewicz, Roth, Li, Cardoso, Meisterernst, Leonhardt: "Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites." in: The Journal of cell biology, Vol. 183, Issue 5, pp. 769-76, (2008) (PubMed).

Batta, Kundu: "Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications." in: Molecular and cellular biology, Vol. 27, Issue 21, pp. 7603-14, (2007) (PubMed).

Target Details for SUB1

Target: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Alternative Name: SUB1 (SUB1 Products)

Synonyms: P15 antibody, PC4 antibody, p14 antibody, AI842364 antibody, P9 antibody, Pc4 antibody, Rpo2tc1 antibody, SUB1 homolog, transcriptional regulator antibody, SUB1 homolog (S. cerevisiae) antibody, SUB1 antibody, Sub1 antibody

Background: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Molecular Weight: 14395

NCBI Accession: NP_006704

UniProt: P53999