This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This STAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 717-745 amino acids from the C-terminal region of human STAT1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Yang, Shen, Xu, Yang, Tsai, Keng, Chen, Lee: "Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition." in: Scientific reports, Vol. 7, Issue 1, pp. 7958, (2017) (PubMed).
Clarke, Clifford, Jindarat, Proud, Pang, Belvisi, Knox: "TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29101-10, (2010) (PubMed).
Sakamoto, Qin, Navarro, Gamero, Potla, Yi, Zhu, Baker, Feldman, Larner: "Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3245-53, (2004) (PubMed).
Zhang, Cho, Petersen, Zhu, Dong: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).
Target
STAT1
(Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
CANDF7 antibody, ISGF-3 antibody, STAT91 antibody, 2010005J02Rik antibody, AA408197 antibody, XStat1 antibody, STAT4 antibody, DD6G4-4 antibody, STAT antibody, STAT1 antibody, dZ182H3.3 antibody, si:by134g18.2 antibody, si:by51f19.1 antibody, si:dz182h3.3 antibody, si:dz199m19.1 antibody, si:dz73o4.2 antibody, stat1 antibody, signal transducer and activator of transcription 1 antibody, signal transducer and activator of transcription 1 L homeolog antibody, signal transducer and activator of transcription 1, 91kDa antibody, signal transducer and activator of transcription 4 antibody, signal transducer and activator of transcription 1a antibody, STAT1 antibody, Stat1 antibody, stat1.L antibody, stat4 antibody, stat1a antibody
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].