SPTLC2 antibody (AA 372-401)

Catalog No. ABIN1881828

Product Details anti-SPTLC2 Antibody

Target: SPTLC2 (serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))

Binding Specificity: AA 372-401

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTLC2 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPTLC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-401 amino acids from the Central region of human SPTLC2.

Clone: RB42738

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SPTLC2 antibody (ABIN1881828)

Rotthier, Auer-Grumbach, Janssens, Baets, Penno, Almeida-Souza, Van Hoof, Jacobs, De Vriendt, Schlotter-Weigel, Löscher, Vondráček, Seeman: "Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I." in: American journal of human genetics, Vol. 87, Issue 4, pp. 513-22, (2010) (PubMed).

Han, Gupta, Gable, Niranjanakumari, Moitra, Eichler, Brown, Harmon, Dunn: "Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 20, pp. 8186-91, (2009) (PubMed).

Chen, Han, Dietrich, Dunn, Cahoon: "The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase." in: The Plant cell, Vol. 18, Issue 12, pp. 3576-93, (2007) (PubMed).

Hornemann, Wei, von Eckardstein: "Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?" in: The Biochemical journal, Vol. 405, Issue 1, pp. 157-64, (2007) (PubMed).

Target Details for SPTLC2

Target: SPTLC2 (serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))

Alternative Name: SPTLC2 (SPTLC2 Products)

Synonyms: HSN1C antibody, LCB2 antibody, LCB2A antibody, NSAN1C antibody, SPT2 antibody, hLCB2a antibody, sptlc2 antibody, zgc:110661 antibody, AI173915 antibody, mKIAA0526 antibody, Pomt2 antibody, LCB2a antibody, SPTLC2 antibody, serine palmitoyltransferase long chain base subunit 2 antibody, serine palmitoyltransferase 2 antibody, serine palmitoyltransferase, long chain base subunit 2 S homeolog antibody, serine palmitoyltransferase, long chain base subunit 2a antibody, serine palmitoyltransferase, long chain base subunit 2 antibody, SPTLC2 antibody, LOC100446763 antibody, sptlc2 antibody, sptlc2.S antibody, sptlc2a antibody, Sptlc2 antibody

Background: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.

Molecular Weight: 62924

NCBI Accession: NP_004854

UniProt: O15270