SPANXB1 antibody (AA 17-47)

Catalog No. ABIN1881824

Product Details anti-SPANXB1 Antibody

Target: SPANXB1 (SPANX Family, Member B1 (SPANXB1))

Binding Specificity: AA 17-47

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPANXB1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPNXB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the Central region of human SPNXB.

Clone: RB42680

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SPANXB1 antibody (ABIN1881824)

Hansen, Eichler, Fullerton, Carrell: "SPANX gene variation in fertile and infertile males." in: Systems biology in reproductive medicine, Vol. 55, pp. 18-26, (2010) (PubMed).

Hansen, Nielsen, Retelska, Larsen, Leffers: "A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family." in: Molecular reproduction and development, Vol. 75, Issue 2, pp. 219-29, (2007) (PubMed).

Kouprina, Pavlicek, Noskov, Solomon, Otstot, Isaacs, Carpten, Trent, Schleutker, Barrett, Jurka, Larionov: "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27." in: Genome research, Vol. 15, Issue 11, pp. 1477-86, (2005) (PubMed).

Zendman, Zschocke, van Kraats, de Wit, Kurpisz, Weidle, Ruiter, Weiss, van Muijen: "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines." in: Gene, Vol. 309, Issue 2, pp. 125-33, (2003) (PubMed).

Target Details for SPANXB1

Target: SPANXB1 (SPANX Family, Member B1 (SPANXB1))

Abstract: SPANXB1 Products

Synonyms: B1 antibody, CT11.2 antibody, SPANX-B antibody, SPANXB antibody, SPANX family member B1 antibody, SPANXB1 antibody

Background: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B1 and appears to be a duplication of that locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis.

Molecular Weight: 11840

NCBI Accession: NP_115850, NP_620588, NP_663697

UniProt: Q9NS25