SMAD5 antibody (AA 241-269)

Catalog No. ABIN1881816

Product Details anti-SMAD5 Antibody

Target: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Binding Specificity: AA 241-269

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD5 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SMAD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the Central region of human SMAD5.

Clone: RB40948

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SMAD5 antibody (ABIN1881816)

Yang, Li, Al-Lamki, Southwood, Zhao, Lever, Grimminger, Schermuly, Morrell: "Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo." in: Circulation research, Vol. 107, Issue 2, pp. 252-62, (2010) (PubMed).

Tao, Sampath: "Alternative splicing of SMADs in differentiation and tissue homeostasis." in: Development, growth & differentiation, Vol. 52, Issue 4, pp. 335-42, (2010) (PubMed).

Park, Lee, Ahn, Kim: "Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity." in: Molecular bioSystems, Vol. 5, Issue 8, pp. 844-53, (2009) (PubMed).

Middlebrook, Eldin, Li, Shivasankaran, Pangas: "Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors." in: Endocrinology, Vol. 150, Issue 12, pp. 5208-17, (2009) (PubMed).

Su, Zhu, Han, Feng, Huang, Ren, Pan, Zhang, Lu, Huang: "BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12153-64, (2009) (PubMed).

Target Details for SMAD5

Target: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Alternative Name: SMAD5 (SMAD5 Products)

Synonyms: DWFC antibody, JV5-1 antibody, MADH5 antibody, Madh5 antibody, SBN antibody, fb67b04 antibody, mad antibody, madh5 antibody, sb:cb400 antibody, smd5 antibody, wu:fb67b04 antibody, SMAD5 antibody, DKFZp468M0619 antibody, 1110051M15Rik antibody, AI451355 antibody, Dwf-C antibody, MusMLP antibody, SMAD family member 5 antibody, SMAD5 antibody, Smad5 antibody, smad5 antibody

Background: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Molecular Weight: 52258

NCBI Accession: NP_001001419, NP_001001420, NP_005894

UniProt: Q99717