SIKE1 antibody (N-Term)

Catalog No. ABIN1881808

Product Details anti-SIKE1 Antibody

Target: SIKE1 (Suppressor of IKBKE 1 (SIKE1))

Binding Specificity: AA 36-63, N-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIKE1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Sike1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-63 amino acids from the N-terminal region of mouse Sike1.

Clone: RB42417

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SIKE1 antibody (ABIN1881808)

Katayama, Tomaru, Kasukawa, Waki, Nakanishi, Nakamura, Nishida, Yap, Suzuki, Kawai, Suzuki, Carninci, Hayashizaki, Wells, Frith, Ravasi, Pang, Hallinan, Mattick, Hume, Lipovich, Batalov et al.: "Antisense transcription in the mammalian transcriptome...." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1564-6, (2005) (PubMed).

Target Details for SIKE1

Target: SIKE1 (Suppressor of IKBKE 1 (SIKE1))

Alternative Name: Sike1 (SIKE1 Products)

Background: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus-and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity).

Molecular Weight: 23522

NCBI Accession: NP_079955

UniProt: Q9CPR7