This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SCNN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-332 amino acids from the Central region of human SCNN1B.
SCNN1B
Reactivity: Rat
WB, IHC
Host: Mouse
Monoclonal
7B8
FITC
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Song, Wei, Zhou, Lazrak, Liu, Londino, Squadrito, Matalon: "Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9716-28, (2010) (PubMed).
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
Azad, Rauh, Vermeulen, Jaspers, Korbmacher, Boissier, Bassinet, Fichou, des Georges, Stanke, De Boeck, Dupont, Balascáková, Hjelte, Lebecque: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, (2009) (PubMed).
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.