RGS13 antibody (AA 61-90)

Catalog No. ABIN1881748

Product Details anti-RGS13 Antibody

Target: RGS13 (Regulator of G-Protein Signaling 13 (RGS13))

Binding Specificity: AA 61-90

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS13 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RGS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the Central region of human RGS13.

Clone: RB40445

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-RGS13 antibody (ABIN1881748)

Wang, Lippman, Lee, Yang, Khuri, Kim, Lin, Chang, Lotan, Hong, Wu: "Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma." in: Carcinogenesis, Vol. 31, Issue 10, pp. 1755-61, (2010) (PubMed).

Bansal, DiVietro, Kuehn, Rao, Nocka, Gilfillan, Druey: "RGS13 controls g protein-coupled receptor-evoked responses of human mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 11, pp. 7882-90, (2008) (PubMed).

Han, Huang, Kim, Kehrl: "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization." in: Journal of leukocyte biology, Vol. 79, Issue 6, pp. 1357-68, (2006) (PubMed).

Islam, Asplund, Lindvall, Nygren, Liden, Kimby, Christensson, Smith, Sander: "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma." in: Leukemia, Vol. 17, Issue 9, pp. 1880-90, (2003) (PubMed).

Target Details for RGS13

Target: RGS13 (Regulator of G-Protein Signaling 13 (RGS13))

Alternative Name: RGS13 (RGS13 Products)

Synonyms: RGD1562103 antibody, regulator of G protein signaling 13 antibody, regulator of G-protein signaling 13 antibody, RGS13 antibody, Rgs13 antibody

Background: The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.

Molecular Weight: 19135

NCBI Accession: NP_002918, NP_658912

UniProt: O14921

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling