p107 antibody (C-Term)

Catalog No. ABIN1881732

Product Details anti-p107 Antibody

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Binding Specificity: AA 1007-1035, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p107 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1007-1035 amino acids from the C-terminal region of human RBL1.

Clone: RB40387

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-p107 antibody (ABIN1881732)

Jayadeva, Kurimchak, Garriga, Sotillo, Davis, Haines, Mumby, Graña: "B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29863-73, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Cunningham, Vierkant, Sellers, Phelan, Rider, Liebow, Schildkraut, Berchuck, Couch, Wang, Fridley, Gentry-Maharaj, Menon, Hogdall, Kjaer, Whittemore, DiCioccio, Song, Gayther, Ramus, Pharaoh, Goode: "Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis." in: British journal of cancer, Vol. 101, Issue 8, pp. 1461-8, (2009) (PubMed).

Target Details for p107

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Alternative Name: RBL1 (RBL1 Products)

Synonyms: p107 antibody, prb1 antibody, fj58e06 antibody, wu:fj58e06 antibody, CP107 antibody, PRB1 antibody, AW547426 antibody, retinoblastoma-like 1 L homeolog antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma-like 1 (p107) antibody, retinoblastoma-like 1 antibody, rbl1.L antibody, RBL1 antibody, rbl1 antibody, Rbl1 antibody

Background: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 120847

NCBI Accession: NP_002886, NP_899662

UniProt: P28749

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases