RAB27A antibody (C-Term)

Catalog No. ABIN1881720

Product Details anti-RAB27A Antibody

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Binding Specificity: AA 136-164, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB27A antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RAB27A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the C-terminal region of human RAB27A.

Clone: RB42745

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-RAB27A antibody (ABIN1881720)

Ohbayashi, Mamishi, Ishibashi, Maruta, Pourakbari, Tamizifar, Mohammadpour, Fukuda, Parvaneh: "Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2." in: Pigment cell & melanoma research, Vol. 23, Issue 3, pp. 365-74, (2010) (PubMed).

Meeths, Bryceson, Rudd, Zheng, Wood, Ramme, Beutel, Hasle, Heilmann, Hultenby, Ljunggren, Fadeel, Nordenskjöld, Henter: "Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations." in: Pediatric blood & cancer, Vol. 54, Issue 4, pp. 563-72, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Chattopadhyay, Singh, Phukan, Purkayastha, Kataki, Mahanta, Saxena, Kapur: "Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India." in: Mutation research, Vol. 696, Issue 2, pp. 130-8, (2010) (PubMed).

Wood, Meeths, Chiang, Bechensteen, Boelens, Heilmann, Horiuchi, Rosthøj, Rutynowska, Winiarski, Stow, Nordenskjöld, Henter, Ljunggren, Bryceson: "Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity." in: Blood, Vol. 114, Issue 19, pp. 4117-27, (2009) (PubMed).

Target Details for RAB27A

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Alternative Name: RAB27A (RAB27A Products)

Synonyms: MGC80943 antibody, RAB27A antibody, gs2 antibody, ram antibody, rab27 antibody, MGC89827 antibody, hst18676 antibody, zgc:114135 antibody, GS2 antibody, HsT18676 antibody, RAB27 antibody, RAM antibody, 2210402C08Rik antibody, 2410003M20Rik antibody, 4933437C11Rik antibody, ash antibody, RAB27A, member RAS oncogene family L homeolog antibody, RAB27A, member RAS oncogene family antibody, RAB27A, member RAS oncogene family S homeolog antibody, rab27a.L antibody, RAB27A antibody, rab27a antibody, rab27a.S antibody, Rab27a antibody

Background: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Molecular Weight: 24868

NCBI Accession: NP_004571, NP_899057, NP_899058, NP_899059

UniProt: P51159

Pathways: Peptide Hormone Metabolism