PURA antibody (C-Term)

Catalog No. ABIN1881707

Product Details anti-PURA Antibody

Target: PURA (Purine-Rich Element Binding Protein A (PURA))

Binding Specificity: AA 259-287, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PURA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PURA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the C-terminal region of human PURA.

Clone: RB20224

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PURA antibody (ABIN1881707)

Gazla, Carracedo: "Effect of intracellular Wolbachia on interspecific crosses between Drosophila melanogaster and Drosophila simulans." in: Genetics and molecular research : GMR, Vol. 8, Issue 3, pp. 861-9, (2009) (PubMed).

Kaminski, Darbinyan, Merabova, Deshmane, White, Khalili: "Protective role of Puralpha to cisplatin." in: Cancer biology & therapy, Vol. 7, Issue 12, pp. 1926-35, (2009) (PubMed).

Martins-de-Souza, Gattaz, Schmitt, Rewerts, Maccarrone, Dias-Neto, Turck: "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia." in: European archives of psychiatry and clinical neuroscience, Vol. 259, Issue 3, pp. 151-63, (2009) (PubMed).

Darbinian, Cui, Basile, Del Valle, Otte, Miklossy, Sawaya, Amini, Khalili, Gordon: "Negative regulation of AbetaPP gene expression by pur-alpha." in: Journal of Alzheimer's disease : JAD, Vol. 15, Issue 1, pp. 71-82, (2008) (PubMed).

Wang, Johnson, Kinoshita, Babb, Buckley, Liebes, Melamed, Liu, Kurek, Ossowski, Ferrari: "Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex." in: Cancer research, Vol. 68, Issue 8, pp. 2678-88, (2008) (PubMed).

Target Details for PURA

Target: PURA (Purine-Rich Element Binding Protein A (PURA))

Alternative Name: PURA (PURA Products)

Background: This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

Molecular Weight: 34911

NCBI Accession: NP_005850

UniProt: Q00577