PTRH2 antibody (N-Term)

Catalog No. ABIN1881706

Product Details anti-PTRH2 Antibody

Target: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Binding Specificity: AA 26-55, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTRH2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PTRH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTRH2.

Clone: RB42733

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PTRH2 antibody (ABIN1881706)

Fan, Jiang, Suo, Liu, Xu, Ji, Zhang, Yang: "Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells." in: International journal of oncology, Vol. 35, Issue 2, pp. 359-67, (2009) (PubMed).

Biliran, Jan, Chen, Pasquale, Ruoslahti: "Protein kinase D is a positive regulator of Bit1 apoptotic function." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28029-37, (2008) (PubMed).

Bouchentouf, Benabdallah, Rousseau, Schwartz, Tremblay: "Induction of Anoikis following myoblast transplantation into SCID mouse muscles requires the Bit1 and FADD pathways." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 6, pp. 1491-505, (2007) (PubMed).

De Pereda, Waas, Jan, Ruoslahti, Schimmel, Pascual: "Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity." in: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 8111-5, (2004) (PubMed).

Target Details for PTRH2

Target: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Alternative Name: PTRH2 (PTRH2 Products)

Synonyms: BIT1 antibody, PTH2 antibody, A230072I16Rik antibody, Bit1 antibody, CGI-147 antibody, wu:fj09f02 antibody, zgc:109954 antibody, RGD1306819 antibody, peptidyl-tRNA hydrolase 2 antibody, ptrh2 antibody, CC1G_10259 antibody, ANI_1_1036184 antibody, AOR_1_2082154 antibody, PTRH2 antibody, Ptrh2 antibody

Background: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.

Molecular Weight: 19194

NCBI Accession: NP_057161

UniProt: Q9Y3E5