PRTN3 antibody (C-Term)

Catalog No. ABIN1881695

Product Details anti-PRTN3 Antibody

Target: PRTN3 (Proteinase 3 (PRTN3))

Binding Specificity: AA 228-256, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRTN3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PRTN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-256 amino acids from the C-terminal region of human PRTN3.

Clone: RB40945

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PRTN3 antibody (ABIN1881695)

Kuhl, Korkmaz, Utecht, Kniepert, Schönermarck, Specks, Jenne: "Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 1, pp. 387-99, (2010) (PubMed).

Abdgawad, Gunnarsson, Bengtsson, Geborek, Nilsson, Segelmark, Hellmark: "Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression." in: Clinical and experimental immunology, Vol. 161, Issue 1, pp. 89-97, (2010) (PubMed).

Hajjar, Broemstrup, Kantari, Witko-Sarsat, Reuter: "Structures of human proteinase 3 and neutrophil elastase--so similar yet so different." in: The FEBS journal, Vol. 277, Issue 10, pp. 2238-54, (2010) (PubMed).

Källquist, Rosén, Nordenfelt, Calafat, Janssen, Persson, Hansson, Olsson: "Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells." in: Experimental cell research, Vol. 316, Issue 19, pp. 3182-96, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Target Details for PRTN3

Target: PRTN3 (Proteinase 3 (PRTN3))

Alternative Name: PRTN3 (PRTN3 Products)

Synonyms: ela2 antibody, MGC132250 antibody, ACPA antibody, AGP7 antibody, C-ANCA antibody, CANCA antibody, MBN antibody, MBT antibody, NP-4 antibody, NP4 antibody, P29 antibody, PR-3 antibody, PR3 antibody, mPR3 antibody, proteinase 3 L homeolog antibody, proteinase 3 antibody, prtn3.L antibody, PRTN3 antibody, Prtn3 antibody

Background: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Molecular Weight: 27807

NCBI Accession: NP_002768

UniProt: P24158