PDE6H antibody (AA 4-33)

Catalog No. ABIN1881645

Product Details anti-PDE6H Antibody

Target: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Binding Specificity: AA 4-33

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6H antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, Rat, H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.

Clone: RB40887

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PDE6H antibody (ABIN1881645)

Piri, Gao, Danciger, Mendoza, Fishman, Farber: "A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy." in: Ophthalmology, Vol. 112, Issue 1, pp. 159-66, (2005) (PubMed).

Kajimura, Yamazaki, Morikawa, Yamazaki, Mayanagi: "Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms." in: Journal of structural biology, Vol. 139, Issue 1, pp. 27-38, (2002) (PubMed).

Shimizu-Matsumoto, Itoh, Inazawa, Nishida, Matsumoto, Kinoshita, Matsubara, Okubo: "Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H)." in: Genomics, Vol. 32, Issue 1, pp. 121-4, (1996) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for PDE6H

Target: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Alternative Name: PDE6H (PDE6H Products)

Synonyms: ACHM6 antibody, RCD3 antibody, A930033D18Rik antibody, PDEgamma antibody, Pde6g antibody, phosphodiesterase 6H antibody, phosphodiesterase 6H, cGMP-specific, cone, gamma antibody, PDE6H antibody, Pde6h antibody

Background: This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Molecular Weight: 9074

NCBI Accession: NP_006196

UniProt: Q13956

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling