This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This Mouse Pbk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of mouse Pbk.
PBK
Reactivity: Human
WB, IP
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:1000. WB: 1:1000. IHC-P: 1:25. FC: 1:25
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: "Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 23, pp. 6884-93, (2006) (PubMed).
Fujibuchi, Abe, Takeuchi, Ueda, Shigemoto, Yamamoto, Kito: "Expression and phosphorylation of TOPK during spermatogenesis." in: Development, growth & differentiation, Vol. 47, Issue 9, pp. 637-44, (2005) (PubMed).
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity).