NXT1 antibody (C-Term)

Catalog No. ABIN1881591

Product Details anti-NXT1 Antibody

Target: NXT1 (NTF2-Related Export Protein 1 (NXT1))

Binding Specificity: AA 85-111, C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NXT1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the C-terminal region of human NXT1.

Clone: RB30598

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-NXT1 antibody (ABIN1881591)

Venkatesan, Rual, Vazquez, Stelzl, Lemmens, Hirozane-Kishikawa, Hao, Zenkner, Xin, Goh, Yildirim, Simonis, Heinzmann, Gebreab, Sahalie, Cevik, Simon, de Smet, Dann, Smolyar, Vinayagam, Yu et al.: "An empirical framework for binary interactome mapping...." in: Nature methods, Vol. 6, Issue 1, pp. 83-90, (2008) (PubMed).

Forler, Köcher, Rode, Gentzel, Izaurralde, Wilm: "An efficient protein complex purification method for functional proteomics in higher eukaryotes." in: Nature biotechnology, Vol. 21, Issue 1, pp. 89-92, (2003) (PubMed).

Katahira, Straesser, Saiwaki, Yoneda, Hurt: "Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling." in: The Journal of biological chemistry, Vol. 277, Issue 11, pp. 9242-6, (2002) (PubMed).

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Wiegand, Coburn, Zeng, Kang, Bogerd, Cullen: "Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes." in: Molecular and cellular biology, Vol. 22, Issue 1, pp. 245-56, (2001) (PubMed).

Target Details for NXT1

Target: NXT1 (NTF2-Related Export Protein 1 (NXT1))

Alternative Name: NXT1 (NXT1 Products)

Synonyms: CG12752 antibody, DmNXT1 antibody, Dmel\\CG12752 antibody, Nxt antibody, dNxt antibody, dmNXT antibody, dmNXT1 antibody, dmP15 antibody, nxt1 antibody, p15 antibody, GB14514 antibody, MTR2 antibody, P15 antibody, 1110001N02Rik antibody, NTF2-related export protein 1 antibody, NTF2-related export protein antibody, nuclear transport factor 2 like export factor 1 antibody, nuclear transport factor 2-like export factor 1 antibody, Nxt1 antibody, LOC413378 antibody, Tsp_05214 antibody, NXT1 antibody

Background: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

NCBI Accession: NP_037380

UniProt: Q9UKK6